Morphometric evaluation of great vein of Galen and its clinical implications.

The Galenic venous system plays a vital role in the drainage of blood from deeper parts of the brain. This venous system is contributed by many major veins. These veins are located closer to the pineal gland making the surgical approach in this region difficult. Any accidental injury or occlusion of the vein of Galen could lead to devasting results. Thus, studying the dimensions of the vein of Galen is more important. Hence, we aimed to evaluate the morphometry and trajectory to the vein of Galen. About 100 computed tomographic venography records were evaluated and the length, diameter of vein of Galen, angle between straight sinus and vein of Galen and distance from internal occipital protuberance and roof of fourth ventricle to vein of Galen were studied. The mean length and diameter of vein of Galen were 9.8±2.7 and 4.08±1.04 respectively. The mean angle between straight sinus and vein of Galen was 64.2°. The mean distance between external occipital protuberance and roof of fourth ventricle to vein of Galen were 52±6.9 and 33.3±4.5 respectively. No significant morphometric differences were observed between the age groups as well as between the sexs. The results obtained from this study may be helpful for the neurosurgeons in better understanding of the anatomy of the Galenic venous system and to adopt a safe surgical approach to improve the efficacy of the surgeries of the pineal gland and also in the region of vein of Galen.

Reappraisal of arterial anatomy of thumb.

The nomenclature of arteries supplying the thumb and its sources arteries differs between the studies. This makes difficulty in understanding the irrigation pattern to the thumb. The main purpose of this study was to identify the proper digital arteries supplying the thumb on its radial and ulnar side from both the palmar and dorsal aspect. Also this study aimed to trace its source and classify with proper definition with the review of blood supply to thumb. Dissection was carried out in 55 hands form 28 freshly embalmed adult human cadavers of both genders. The proper digital arteries to the thumb and its source arteries were carefully traced and defined. Thumb receives its dominant blood supply mostly from its palmar side. The ulnar palmar digital artery was seen in all the dissected hand (100.0%) whereas; the radial palmar digital artery was present in 53 hands (96.4%). The radial dorsal digital artery and ulnar dorsal digital artery were observed in only 10.0% and 7.3%. The most common source of both the palmar digital arteries to thumb was from first palmar metacarpal artery (FPMA). In majority of the hands, in addition to the radial or ulnar palmar digital arteries from the FPMA, there were also additional palmar digital arteries arising from the superficial palmar arterial system. The universal naming of the proper digital arteries to the thumb as well as its source arteries is mandatory for the proper understanding of normal as well as variant arterial anatomy of thumb.

Congenital positional anomaly of descending colon and sigmoid colon: Its embryological basis and clinical implications.

The rotation of the midgut is essential for normal placement of intestines in the abdominal cavity. The process of midgut rotation and simultaneous retraction of the herniated intestinal loops pushes the hind gut to the left side of the abdominal cavity. So the descending colon and the sigmoid colon occupy the left side of the abdominal cavity. In this report, we document a male cadaver that revealed right-sided sigmoid colon. On further dissection, the descending colon was found lying in the midline with a small peritoneal fold stretching from the right side of sigmoid colon to ileocecal junction. There was also variation in the inferior mesenteric artery supplying the displaced descending colon and sigmoid colon. The possible embryological and molecular basis of this variation has been discussed. The anatomical knowledge of this variation is essential for interventional and diagnostic colonoscopy procedures and colonic surgeries.

Philadelphia-Like Acute Lymphoblastic Leukemia: A Systematic Review.

Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a subgroup of B-cell precursor ALL (BCP-ALL) with a gene expression profile analogous to Philadelphia-positive ALL and recurrent IKAROS Family Zinc Finger 1 (IKZF1) gene deletion despite lacking BCR-ABL1 (Breakpoint cluster region-ABL protooncogene) translocation. Although recognized to occur at all ages, the proportion of cases among BCP-ALL varies (< 10% in children and up to 30% in adolescents). In all age groups, males are more commonly affected. Generally, Ph-like ALL is associated with adverse clinical features and an increased risk of treatment failure with conventional approaches. Genetic alterations such as aberrant expression, point mutations, or fusion translocations lead to activation of cytokine receptors and signaling kinases, which affect the ABL1 (ABL class fusion) or Janus Kinase (JAK) signaling pathways. Several clinical trials are being conducted to understand whether specific tyrosine kinase inhibitor therapy can improve cure rates. This review summarizes the current literature available about this entity.

Coronary venous anatomy relevant to cardiac resynchronization therapyan angiographic study

Cardiac resynchronization therapy (CRT) in-volves placing a lead through the coronary sinus to pace the left ventricle. However, technical problems arise in the procedure either due to variant anatomy or due to the presence of valves. Information on coronary venous anatomy is scarce in the South Indian population. The aim of this study was to describe the coronary sinus anatomy in patients undergoing CRT implant. Coronary sinus angiograms were used to study the following parameters: (a) Dimensions of coronary sinus (b) Number and distribution of tributaries (excluding middle and great cardiac veins) (c) Diameter of major veins at the origin (d) Angulation of tributaries with CS. Measurements were made using calipers in the dicom viewer. Out of the 24 angiograms studied, only a single tributary of adequate size was noted in 70.8% (17/24) of the cases, which was most commonly a midlateral vein (76.5%). Two prominent tributaries were noted in 29.2% (7/24) of cases. The average diameter of the veins was 3.93 mm and 80.6% of the veins had an obtuse angle of drainage. Anatomical variations in the coronary venous systemin this population suggest that the majority of patients have a single suitable tributary and this is most often the midlateral vein, which is known to have the most favorable outcome. Data obtained in this study will guide clinicians in left ventricular lead placement in the South Indian population leading to greater procedural success

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Newer insights in the anatomy of superficial palmar arch.

PURPOSE: The purpose of the study is to study and classify the superficial palmar arch and its variation based upon the gross dissection and to check the bilateral symmetry of the arches. Specifically, we checked for the presence of the superficial palmar arch as described in the standard textbooks. METHODS: We dissected 55 hands from 28 cadavers of both sexes that include 18 males and 10 females. The superficial palmar arch was carefully dissected and the arteries contributing its formation were traced. It was classified into complete, incomplete arches. Bilateral symmetry of the arches was also studied. RESULTS: The most common pattern of superficial palmar arch observed is complete. And it is further classified into radio-ulnar and predominantly ulnar types. A consistent proportion of radio-ulnar type arch is completed around first web space. None of the dissected hand meets the definition of the classical superficial palmar arch as described in the standard anatomical textbooks. We also encountered few rare variants of the incomplete superficial palmar arch. CONCLUSIONS: Type 1-4 superficial palmar arch is complete and can be utilized for radial artery or ulnar artery cannulation and radial artery harvesting procedure. In type 5 arch, ulnar artery occlusion could lead to severe hand ischemia and at the same time the radial artery in this type can be harvested without ischemic complication. We suggest that the definition of the complete superficial palmar arch should be rechecked and modified as complete superficial palmar or complete superficial first web space arch.

Morphometric study of pulleys of the thumb.

Pulleys are thickened regions in flexor tendons sheaths of the digits. They are essential and act as fulcrum for the flexion and extension of the digits. The arrangement and number of pulley system differs greatly between the thumb and other digits. There is paucity of literature regarding the pulley system of thumb. We aimed to study the morphometry of the pulley system of the thumb in Indian cadavers. Dissection was carried out in 55 adult human cadaveric thumbs. The most common morphologic pattern of pulley observed in the thumb is type III (30 thumbs). The least observed is type I (4 thumbs). The mean width and standard deviation of A1, Av, oblique, and A2 pulleys are 5.06±0.87, 5.38±1.22, 4.68±1.13, and 6.04±1.41 mm, respectively. The gap distances between the pulleys were also measured. The results obtained from the present study may be helpful in surgical treatment of trigger thumb with less complication and also in reconstruction of the closed rupture of the pulley of the thumb.

Topographic anatomical landmarks for pulley system of the thumb.

PURPOSE: Knowledge of anatomical landmark to pulley system of the thumb is essential in successful treatment of trigger thumb release either by percutaneous or by minimally invasive technique. Though surgical release of trigger thumb is done commonly, there is paucity of data in the literature regarding its surface landmarks. The purpose of this study is to identify palmar surface anatomical landmarks to the pulley system of the thumb. METHODS: Dissection was performed on 55 fresh frozen adult cadaveric thumbs. The palmar thumb creases were given names as the proximal-proximal crease (PPC) present at the metacarpophalangeal joint, the distal-proximal crease (DPC) over the middle of the proximal phalanx and the distal crease (DC) at interphalangeal joint. The distance between the proximal edges of each pulley to the three thumb creases and longitudinal length of A1, A2, oblique and Av pulley was measured using digital vernier caliper and was expressed in mean and standard deviation. RESULTS: The proximal edge of A1 pulley was 1.98 ± 1.61 mm proximal to the PPC. The mean longitudinal length of the A1 pulley was measured to be 5.06 ± 0.87 mm, so the distal edge of the A1 pulley was calculated to lie 3.08 mm distal to PPC. The proximal edge of Av and oblique pulley was situated 7.78 ± 2.5 and 15.72 ± 3.22 mm distal to PPC, respectively. The proximal edge of A2 pulley was very nearer and 2.88 ± 1.79 mm proximal to DC. CONCLUSION: The knowledge of anatomical skin surface landmarks is helpful in the percutaneous release or minimally invasive procedure. The PPC serves as a definite landmark for A1, Av and oblique pulley whereas it is the DC for A2 pulley.

Which side are you on? - Deducing the chamber of origin of atrial tachycardia.

Atrial arrhythmias rising from the regions of the atria that are in close proximity to each other may pose a challenge in identifying the chamber to map and ablate in. In this report, we discuss a patient with left atrial tachycardia which initially mimicked right atrial tachycardia. We discuss the origins of the abnormal electrograms in the right atrium and how this provides a general understanding of the mechanism of double potentials.

Morphometric study of tensor of vastus intermedius in South Indian population.

Tensor of vastus intermedius is a newly discovered muscle located between vastus lateralis and vastus intermedius. The purpose of this study was to investigate the detailed morphology of tensor of vastus intermedius, specifically to provide data pertaining to the attachments, innervations, variation in the types and its morphometry in South Indian population. The tensor of vastus intermedius was studied in thirty six cadaveric lower limbs using macrodissection techniques. The origin of the muscle was from upper part of intertrochanteric line and anterior part of greater trochanter of femur inserted to medial aspect of upper border of patella. The muscle was classified into four types based on the origin and also the aponeurosis course with independent type (type 1) being common. The mean and standard deviation of the length of tensor of vastus intermedius and aponeurosis were 145.40±37.55 mm and 193.55±42.32 mm, respectively. The results of the study suggest that tensor of vastus intermedius is variable and the information provided regarding the attachments, types and quantitative data will contribute to the existing knowledge of the muscle.

DNA Damage Analysis in Children with Non-syndromic Developmental Delay by Comet Assay.

INTRODUCTION: Majority of the developmental delays in children are non-syndromic and they are believed to have an underlying DNA damage, though not well substantiated. Hence the present study was carried out to find out if there is any increased DNA damage in children with non-syndromic developmental delay by using the comet assay. AIM: The present case-control study was undertaken to assess the level of DNA damage in children with non syndromic developmental delay and compare the same with that of age and sex matched controls using submarine gel electrophoresis (Comet Assay). MATERIALS AND METHODS: The blood from clinically diagnosed children with non syndromic developmental delay and controls were subjected for alkaline version of comet assay - Single cell gel electrophoresis using lymphocytes isolated from the peripheral blood. The comets were observed under a bright field microscope; photocaptured and scored using the Image J image quantification software. Comet parameters were compared between the cases and controls and statistical analysis and interpretation of results was done using the statistical software SPSS version 20. RESULTS: The mean comet tail length in cases and control was 20.77+7.659µm and 08.97+4.398µm respectively which was statistically significant (p<0.001). Other comet parameters like total comet length and % DNA in tail also showed a statistically significant difference (p < 0.001) between cases and controls. CONCLUSION: The current investigation unraveled increased levels of DNA damage in children with non syndromic developmental delay when compared to the controls.

Junctura Tendinae in the First Intermetacarpal Space: A Case Report.

The anatomy of extensor tendons and juncturae tendinum (JT) is of interest to both anatomists and surgeons. Understanding the structure of the JTs and the interactions between the tendons of the fingers is of utmost importance in hand assessment, especially during the reconstructive procedures such as tendon transfers. During routine dissection of extensor tendons of dorsum of hand there was a filamentous band between the tendon of extensor pollicis longus and extensor indices in the first intermetacarpal space. This band was identified as Juncturae tendinae of Type 1. It was attached to the extensor tendons on either side of the first intermetacarpal space in a transverse direction. The presence of Juncturae tendinae in the first intermetacarpal space is a rare variation. This variation is important as it interferes with independent motion of thumb and index finger and also in tendon repairs.

Perception of MBBS students to "flipped class room" approach in neuroanatomy module.

A flipped classroom is a learner centered approach in which the learner is responsible to attend the class with basic understanding of the subject to fully participate and engage in discussions. The aim of this study was to evaluate students' perception of flipped classroom approach for neuroanatomy module and assess the impact on their performance and attitudes. The subject chosen to evaluate the flipped classroom model for first year medical students was clinical neuroanatomy. One hundred and thirty first year medical students participated in the study module. Students were divided into five groups and five case scenarios pertaining to various clinically relevant regions of the neuraxis, with varying anatomical complexity were generated. The pre- and post-tests were designed to specifically test the declared learning objectives of the session. The perception of the students regarding this model of teaching and learning was also evaluated. Eighty-six percent of students felt that the flipped classroom approach was better at fulfilling the stated learning objectives than the conventional didactic teaching, 92% felt that the work-sheet with questions provided prior to the class enabled a better understanding of the subject and 87% were of the opinion that the web sources with references kindled a greater interest to read as compared with didactic lectures. The paired t test showed highly significant differences between the pre and post-test scores. Student response to the flipped classroom structure was largely positive, indicating it to be an approach worth pursuing in future years.

Variations in the branching pattern of posterior division of mandibular nerve: a case report.

PURPOSE: Abnormal communications among the branches of mandibular nerve especially the posterior division are significant due to various procedures undertaken in this region. These variations are worth reporting as they pose serious implications in several interventions in this region, and may even lead to false diagnosis. METHODS: During routine dissection, the mandibular nerve and its branches were dissected in the infratemporal fossa. The branches from the posterior division of the mandibular nerve namely the inferior alveolar and auriculotemporal nerves were carefully dissected, and their abnormal branching pattern was noted. RESULTS: There was a communicating branch between left inferior alveolar and auriculotemporal nerve. There was also a variant recurrent branch from the left inferior alveolar nerve that supplied the lateral pterygoid muscle. CONCLUSIONS: Such variant branches and communications between the branches of mandibular nerve as seen in this case have an embryological basis and are clinically important in this region especially for dental surgeries and anesthesia.

Anatomical variations of the aortic knob in chest radiographs

There is a paucity of data regarding the normal anatomical variations of the aortic knob (AK) on routine postero-anterior chest radiographs (PACR). The aims of the present study were to document and analyze the anatomical variations of the AK on PACRs’ in an adult Indian population. This was a crosssectional study of PACRs’ in a tertiary care hospital with attached medical college in Bangalore, India. The AKs’ in 108 (77 males and 31 females) PACRs’ of normal, healthy adults were studied using the following measurements: minimum distance of the left edge of the aortic knuckle from the midline (AKW); straight and curved length of the AK (AKS and AKC). The ratio of the AKC to the AKS was calculated and termed the AK index (AKI). The mean and standard deviation were determined for AKW, AKS and AKI. The unpaired t-test was used to check for significant sex differences in the above parameters. Spearman’s rank order correlation coefficient of the AKW, AKS and AKI with the age, BMI, CD, CA and CTR was calculated. The mean value of the AKW was significantly higher in males as compared to females. The majority of the values of AKI were between 1 and 1.2 in both sexes. The AKW showed significant positive correlations with age, the body mass index and cardiac diameter. The AKI showed a weak, although significant positive correlation with the age and the cardiothoracic ratio. The present study describes the anatomical variations of the AK, using the AKI to quantify its prominence (AU)

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